Nucleotide Oligomerization Binding Domain-Like Receptor Signaling Enhances Dendritic Cell-Mediated Cross-Priming In Vivo

Oligomerization Domain-like Receptor TLR and Nucleotide-Binding

Toll-like Receptor (TLR) and Nucleotide-Binding Oligomerization Domain (NOD) Signaling during Vibrio cholerae Infection

Submit Manuscript | http://medcraveonline.com expression of ToxT [8,9]. ToxR acts as a master regulator and remains under the control of environmental factors [10]. ToxR directly regulates the expression of the outer membrane porin proteins OmpU and OmpT in a separate branch of the ToxR cascade independent of TcpP and ToxT [11,12] which has been suggested to be involved in adherence during path...

Nucleotide-Binding Oligomerization Domain

Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis.

BACKGROUND Pattern recognition receptor nucleotide-binding oligomerization domain 2 (NOD2) is well investigated in immunity, but its expression and function in platelets has never been explored. METHOD AND RESULTS Using reverse transcription polymerase chain reaction and Western blot, we show that both human and mouse platelets express NOD2, and its agonist muramyl dipeptide induced NOD2 acti...

The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.

Nucleotide-binding oligomerization domain-like receptors (NLRs) are a group of intracellular proteins that mediate recognition of pathogen-associated molecular patterns or other cytosolic danger signals. Mutations in NLR genes have been linked to a variety of inflammatory diseases, underscoring their pivotal role in host defense and immunity. This report describes the genomic organization and r...